Moore Laboratory

Selected Publications

Nguyen APT, Tsika E, Kelly K, Levine N, Chen X, West AB, Boularand S, Barneoud P, Moore DJ. Pre-print. Dopaminergic neurodegeneration induced by Parkinson’s disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. bioRxiv.

Beilina A, Bonet-Ponce L, Kumaran R, Kordich JJ, Ishida M, Mamais A, Kaganovich A, Saez-Atienzar S, Gerschlick DC, Roosen DA, Pellegrini L, Malkov V, Fell MJ, Harvey K, Bonifacino JS, Moore DJ, Cookson MR. 2020. The Parkinson’s disease protein LRRK2 interacts with the GARP complex to promote retrograde transport to the trans-Golgi network. Cell Rep 31(5):107614.

Cunningham LA, Moore DJ. 2020. Endosomal sorting pathways in the pathogenesis of Parkinson’s disease. Prog Brain Res 252:271–306.

Patterson JR, Duffy MF, Kemp CJ, Howe JW, Collier TJ, Stoll AC, Miller KM, Patel P, Levine N, Moore DJ, Luk KC, Fleming SM, Kanaan NM, Paumier KL, El-Agnaf OMA, Sortwell CE. 2019. Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils. Neurobiol Dis.

Wang X, Becker K, Levine N, Zhang M, Lieberman AP, Moore DJ, Ma J. 2019. Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration. Acta Neuropathol Commun 7(1):41.

Chen X, Kordich JK, Williams ET, Levine N, Cole-Strauss A, Marshall L, Labrie V, Ma J, Lipton JW, Moore DJ. 2019. Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A.

Williams ET, Glauser L, Tsika E, Jiang H, Islam S, Moore DJ. 2018. Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting. Hum Mol Genet.

Williams ET, Moore DJ. 2018. Deciphering the role of VPS35 in Parkinson’s disease. J Neurosci Res 96(8):1339–1340.

Nguyen APT, Moore DJ*. 2017. Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity. Adv Neurobiol 14:71-88. 

Tran Nguyen AP, Daniel G, Valdés P, Islam MS, Schneider BL, Moore DJ. 2017. G2019S LRRK2 enhances the neuronal transmission of Tau in the mouse brainHum Mol Genet 27(1):120–134.

Williams ET, Chen X, Moore DJ. 2017. VPS35, the retromer complex and Parkinson’s diseaseJ Parkinsons Dis 7(2):219–233.       

Islam MS, Moore DJ. 2017. Mechanisms of LRRK2-dependent neurodegeneration: Role of enzymatic activity and protein aggregationBiochem Soc Trans45(1):163–172.      

Zheng L, Bernard-Marisassal N, Moullan N, D’Amico D, Auwerx J, Moore DJ, Knott G, Aebischer P, Schneider BL. 2017. Parkin functionally interacts with PGC-1a to preserve mitochondria and protect dopaminergic neuronsHum Mol Genet 26(3):582–598.      

Islam MS, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean T, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M. 2016. Human R1441C LRRK2 regulates the synaptic vesicle preteome and phosphoproteome in a Drosophila model of Parkinson’s diseaseHum Mol Genet 25(24)5356–5382.        

Nucifora Jr FC, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, Dawson TM, Smith W, Lim KL, Ross CA. 2016. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1Nat Commun7:11792.  

Klionsky DJ…Moore DJ…Zughaier SM. 2016. Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy 12(1):1–222.     

Tsika E, Nguyen AP, Dusonchet J, Colin P, Schneider BL, Moore DJ. 2015. Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson’s diseaseNeurobiol Dis 77:49–61.

Daniel G, Musso A, Tsika E, Fiser A, Glauser L, Pletnikova O, Schneider BL, Moore DJ. 2014. α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson’s disease occurs independent of ATP13A2 (PARK9)Neurobiol Dis 73C:229–243.      

Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B. 2014. A Parkinson’s disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityHum Mol Genet 23(18):4887–4905.     

Daniel G, Moore DJ. Modeling LRRK2 pathobiology in Parkinson’s disease: From yeast to rodents. In: Geyer M, Ellenbroek B, Marsden C, editors. Current Topics in Behavioral Neuroscience: Springer Berlin Heidelberg; c2014.     

Tsika E, Kannan M, Foo CS, Dikeman D, Glauser L, Gellhaar S, Galter D, Knott GW, Dawson TM, Dawson VL, Moore DJ. 2014. Conditional expression of Parkinson’s disease-related R1441C LRRK2 in midbrain dopamineragenic neurons of mice causes nuclear abnormalities without neurodegeneration. Neurobiol Dis 71 C:345–358.     

Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin UM, Lees A, Troncoso JC, Lewis PA, Bandopadhyay R, Schneider BL, Moore DJ. 2014. Parkinson’s disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet 23(17):4621–4638.    

Stafa K, Tsika E, Moser R, Musso A, Glauser L, Jones A, Biskup S, Xiong Y, Bandopadhyay R, Dawson VL, Dawson TM, Moore DJ. 2014. Functional interaction of Parkinson’s disease-associated LRRK2 with members of the dynamin GTPase superfamilyHum Mol Genet 23(8):2055–2077.     

Tsika E, Moore DJ. 2013. Contribution of GTPase activity to LRRK2-associated Parkinson’s diseaseSmall GTPases 4(3):164–170.   

Biosa A, Trancikova A, Civiero L, Glauser L, Bubacco L, Greggio E, Moore DJ. 2013. GTPase activity regulates kinase activity and cellular phenotypes of Parkinson’s disease-associated LRRK2Hum Mol Genet 22(6):1140–1156.     

Trancikova A, Mamais A, Webber PJ, Stafa K, Tsika E, Glauser L, West AB, Bandopadhyay R, Moore DJ. 2012. Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutationsPLoS One 7(10): e47784.    

Podhajska A, Musso A, Trancikova A, Stafa K, Moser R, Glauser L, Sonnay S, Moore DJ. 2012. Common pathogenic effects of missense mutations in the P-type ATPase ATP13A2 (PARK9) associated with early-onset parkinsonismPLoS One 7(6): e39942.     

Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ. 2012. Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2Hum Mol Genet 21(11):2420–2431.     

Stafa K, Trancikova A, Webber PJ, Glauser L, West AB, Moore DJ. 2012. GTPase activity and neuronal toxicity of Parkinson’s disease-associated LRRK2 is regulated by ArfGAP1PLoS Genet 8(2):e1002527.     

Ramonet D, Podhajska A, Stafa K, Sonnay S, Trancikova A, Tsika E, Pletnikova O, Troncoso JC, Glauser L, Moore DJ. 2012. PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrityHum Mol Genet 15(21):1725–1743.     

Glauser L, Sonnay S, Stafa K, Moore DJ. 2011. Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1J Neurochem 118(4):636–645.    

Ramonet D, Daher JPL, Lin BM, Stafa K, Kim J, Banerjee R, Westerlund M, Pletnikova O, Glauser L, Yang L, Liu Y, Swing DA, Beal MF, Troncoso JC, McCaffery JM, Jenkins NA, Copeland NG, Galter D, Thomas B, Lee MK, Dawson TM, Dawson VL, Moore DJ. 2011. Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2PLoS One 6(4):e18568.   

Dusonchet J, Kochubey O, Stafa K, Young SM, Zufferey R, Moore DJ, Schneider BL, Aebischer P. 2011. A rat model of progressive nigral neurodegeneration induced by the Parkinson’s disease-associated G2019S mutation in LRRK2J Neurosci 3(3):907–912.    

Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ. 2010. GTPase activity plays a key role in the pathobiology of LRRK2PLoS Genet 6(4):e1000902.     

Daher JPL, Ying M, Banerjee R, McDonald RS, Hahn MD, Yang L, Beal MF, Thomas B, Dawson VL, Dawson TM, Moore DJ. 2009. Conditional transgenic mice expressing C-terminally truncated human a-synuclein (aSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neuronsMol Neurodegen 4:34.